Dilated cardiomyopathy (DCM) and taurine

Ana always ready for more food.

Heart disease affects about 10-15% of all cats and dogs. Dilated cardiomyopathy (DCM) is a genetic heart condition in dogs, typically larger breeds like Doberman Pinscher, Great Dane, or the Irish Wolfhound. It is also seen in Cocker Spaniels associated with taurine deficiency but I’ll get to taurine in a bit. Interestingly, the FDA has seen a bias in reporting of DCM in Golden Retrievers and they believe it’s due to breed specific social media groups that have raised awareness of DCM. DCM presents slowly and its presentation is similar to congestive heart failure (CHF). DCM can actually become CHF.

Is grain-free diet the cause of DCM in atypical breeds? It’s not clear. The FDA is studying the situation. You can read more from their latest announcement. In some cases, blood tests have shown low levels of taurine and a change of diet combine with taurine supplements have reversed DCM in atypical breeds. Again, it’s not clear if the grain-free diets are causing DCM simply because there is low levels of taurine or if it has something to do with specific ingredients found in grain-free dog food, e.g., peas and legumes. Tufts University wrote a good introduction/summary of DCM and grain-free food.

So what is taurine and what’s the big deal? Taurine is an amino acid. Amino acids are the building blocks for proteins. Both humans and dogs can make taurine from methionine (an essential amino acid) and cysteine (a nonessential amino acid). As a refresher, essential amino acids are required in our diets. We cannot produced them. Conversely, nonessential amino acids are produced in our bodies. There are 20 amino acids (9 are essential) that are common in proteins. Taurine isn’t one of them. So what’s the fuss? Again, it isn’t clear what is going on with DCM, grain-free diets, and taurine. The FDA is still investigating.

What should you do? As always, try to educate yourself as much as possible. Chicken and turkey are high in taurine, especially dark meat. Perhaps rotating your pet’s diet will help while the research continues. Another thing you can do is learn to read dog food labels. You should be familiar with the AAFCO nutrient profile. Don’t worry about which ingredient is first, second, etc. Base your pet’s diet on facts and science. Talking to your vet, especially a veterinary nutritionist, is a lot more sensible than misguided advice on the Internet or word-of-mouth.

When we first got our dog (she’s a rescue), she had diarrhea. The vet said she had worms so we de-wormed her. Anytime a dog has digestive problems, we always switch to a bland diet: rice, pumpkin, and a little chicken meat. Every time we put Ana back on her puppy food, she got diarrhea again. We knew she was worm free, so we figured it might be the food. It was a reputable brand. We stumbled on the Dog Food Advisor website and figured out that Ana is allergic to corn meal. So we learned to read labels for exotic and/or questionable ingredients. Dog Food Advisor listed corn meal as a questionable ingredient. Check out their advice on grain-free diet and DCM.

Here’s another good resource to get up to speed with taurine and DCM.

New kg definition: Kibble Balance

New kg definition: Kibble Balance

By now, many of you should have heard that the kg is being redefined.

You can read more about it here:

https://www.sciencemag.org/news/2018/11/metric-system-overhaul-will-dethrone-one-true-kilogram

For 130 years, the kilogram (kg) was defined by a cylinder of platinum-iridium alloy in Sèvres, France. You should also know that scientists and standards agencies have been trying to define SI units with measurable techniques based on physical constants. Here’s an example and an explanation of the new kilogram definition from the article above:

The new SI generalizes the trade-off already exploited to define the meter more precisely in terms of the speed of light. Until 1983, light’s speed was something to be measured in terms of independently defined meters and seconds. However, that year, the 17th CGPM defined the speed of light as exactly 299,792,458 meters per second. The meter then became the measurable thing: the distance light travels in 1/299,792,458 seconds. (The second was pegged to the oscillations of microwave radiation from cesium atoms in 1967.)

The new SI plays the same game with the other units. For example, it defines the kilogram in terms of the Planck constant, which pops up all over quantum mechanics. The constant is now fixed as exactly 6.62607015×10-34 kilogram meters squared per second. Because the kilogram appears in that definition, any experiment that previously measured the constant becomes a way to measure out a kilogram instead.

Such experiments are much harder than clocking light speed, a staple of undergraduate physics. One technique employs a device called a Kibble balance, which is a bit like the mythical scales of justice. A mass on one side is counterbalanced by the electric force produced by an electrical coil on the other side, hanging in a magnetic field. To balance the weight, a current must run through the coil. Researchers can equate the mass to that current times an independent voltage generated when they remove the mass and move the coil up and down in the magnetic field.

That’s were the Kibble balance comes in and the linked article below does a better job of explaining it than I could.

https://www.nist.gov/si-redefinition/kilogram-kibble-balance

Basic Science for the sake of curiosity

Basic Science for the sake of curiosity

We can’t always put a dollar amount on basic science research, especially when politicians want to talk about return-on-investment when discussing funding basic science research. There are so many examples of breakthroughs that build on a wealth of knowledge that started out as a curiosity in basic science research. Good examples of seeing the value of basic science research (and then losing sight of it) are Bell Labs and Xerox PARC. Look at all of their contributions to everyday technology and science, yet they were eventually closed down.

Although it’s preaching to the choir, please read this excellent post from Buddhini Samarasinghe.

Originally shared by Buddhini Samarasinghe

Nanopore sequencing: a story about discovery science

Ever since I began a career as a scientist (and even more so as a science communicator now), I’ve been a passionate advocate for discovery science. ‘Discovery science’ is a term used interchangeably with ‘basic science’, or ‘blue skies research’, but essentially it means curiosity-driven research rather than a specific goal-oriented research programme. Discovery science asks open ended questions, like “what does this protein do?” as opposed to “how do you block this protein so we can make a new drug?”.

Many of the serendipitous discoveries in science, especially the ones that improved our lives, happened the way they did because there already existed a strong scientific base upon which to develop those initial ideas. Put another way, no matter how healthy a seedling is, it won’t grow and flourish unless the soil it’s growing on is fertile.

But tracking these stories is not easy – how do you look at a technology that exists now, a technology that we take for granted, and then attribute it’s existence to previous discoveries? We like to quote Newton’s “If I have seen further, it is by standing on the shoulders of giants” but can we actually find out exactly who those giants were?

Several months ago, I started asking this question in the very specific context of genome sequencing. We are now at a place where genome sequencing is unimaginably easy and cheap compared to how it used to be several decades ago. For about $1000, you can buy a portable USB powered DNA sequencer that is the size and weight of a chocolate bar, and hook it up to a laptop. This technology, known as ‘nanopore sequencing’, would not have been possible were it not for decades of discovery science preceding it. Even more interesting is the fact that the pioneer of nanopore sequencing didn’t even set out with the intention of developing a brand new, disruptive sequencing technology; he started out studying a tiny protein found in a humble bacterial species!

I hope that this story highlights the importance of curiosity-driven research, and the unexpected benefits we can glean from them. It took me a while to pull these disparate threads together to weave this story, and yes a lot of it does have a focus on the UK’s Medical Research Council’s work (because I did this as part of my day job, yay!). But I hope you enjoy it, and more importantly, are inspired to advocate for discovery science like I am, because we probably need it now more than ever.

https://mrc.ukri.org/news/browse/decades-of-discovery-set-to-revolutionise-healthcare/

https://mrc.ukri.org/news/browse/decades-of-discovery-set-to-revolutionise-healthcare/

Nikon Small World challenge 2018

Nikon Small World challenge 2018

I wished The Atlantic would have reminded people that these are often colorized. When you use fluorescent microscopy the images are greyscale and people often colorize them later. Note, a lot of the images are NOT fluorescent.

https://www.theatlantic.com/photo/2018/10/photographing-the-microscopic-winners-nikon-small-world-2018/572737/?utm_medium=social&utm_term=2018-10-12T01:37:23&utm_source=twitter&utm_campaign=the-atlantic&utm_content=edit-promo

4 Personality types, only 4?

4 Personality types, only 4?

By now, I’m sure many of you have read about the 4 personality types that have come out of the research from Profs. Amaral and Revelle at Northwestern University. I think it’s interesting to see engineering and psychology come together for a study like this.

https://news.northwestern.edu/stories/2018/september/are-you-average-reserved-self-centered-or-a-role-model/

Primal Posture

Primal Posture

I plan to investigate a bit more on the work by Esther Gokhale on “primal posture”. Here’s her TED talk.

https://www.youtube.com/watch?v=k1luKAS_Xcg

It kind of makes sense but I’d like to learn more. I heard this on the radio on the way to work then saw it posted by Jennifer Freeman

https://www.npr.org/sections/goatsandsoda/2018/08/13/636025077/to-fix-that-pain-in-your-back-you-might-have-to-change-the-way-you-sit