Chemophobia: irrational plague?

Chemophobia: irrational plague?

An article from Slate, Don’t Take Medical Advice From the New York Times Magazine http://goo.gl/EYaFh is being re-shared and discussed quite a bit on G+. So h/t to Gaythia Weis Jennifer Ouellette Mary Mangan and Google Plus Science Lab 

It’s a great article about chemophobia and discusses a story about a mother who would rather give her child some Chinese medicine rather than what the “Western doctor” prescribed. It points out that supplements are not heavily regulated and so the dose and composition of the supplements can vary wildly. So you actually don’t know what you are getting.

When I come across people who display signs of chemophobia or who try to promote only “natural” products, I try my best to politely remind them that snake bites are natural too. Arsenic, cyanide, carbon monoxide can be deadly and are very much natural. You can get any of those three chemicals, naturally from the environment. In fact you probably have traces of arsenic in your blood.

Here’s an old post about rhubarb, natural and delicious.

Rhubarb poisoning not from a rube

http://goo.gl/Y5546

I was going to use a belladonna plant for the main picture as belladonna can be poisonous. Atropa belladonna http://en.wikipedia.org/wiki/Belladonna_(plant)

Note that atropine is derived from belladonna and it can be used medicinally (Western medicine) for bradycardia (low heart rate) and ironically to counteract organophosphate poisoning (it’s not an antidote, it blocks the action of acetylcholine). http://en.wikipedia.org/wiki/Atropine

Which brings me to another one of my favorite comments when it comes to chemophobia.

Alle Ding’ sind Gift, und nichts ohn’ Gift; allein die Dosis macht, daß ein Ding kein Gift ist.

“All things are poison, and nothing is without poison; only the dose permits something not to be poisonous.” Paracelsus

The only real difference between medicine and poison is the dose….and intent. Oscar G. Hernandez, MD

Here’s another good article about chemophobia.

The best antidote for this irrational plague of fear is the same as it usually is: good science, clearly understood, and openly available to all. Seymour Garte, Ph.D.

Our Chemophobia Conundrum

http://goo.gl/ZUc15

The picture is from a NY Times article that was discussed here.

Who can resist?: #Chemophobia in the NYT

http://goo.gl/c5Bj0

Ultimately, this is a problem of psychology. In the age of high-investment parenting, threats to our children can overrun any rational defense a parent might be able to construct…  As a chemist, I find chemophobia pretty ridiculous. As a parent, I’m in sympathy — we all fear unknown threats to our kids. I merely ask that parents step back from genuine fear-mongering that we get from Environmental Working Group and the like and try to gain a rational, risk-based perspective on chemicals in the home.

Finally, here is another article that made the rounds on G+.

America’s Real Criminal Element: Lead

http://goo.gl/7RTdZ

#ScienceEveryday  when it isn’t #ScienceSunday  

I leave you with.

Culture Club – Church Of The Poison Mind

Foxo TRAIL

Foxo TRAIL

Dr. Wafik S. El-Deiry and colleagues at Penn State University developed a new drug, TRAIL-inducing compound 10 (TIC10). What is TRAIL and what’s the big deal?

TRAIL is tumor necrosis factor-related apoptosis-inducing ligand. It’s a protein in our immune system that induces apoptosis (programmed cell death) in tumors. The problem with recombinant versions, i.e., man-made versions intended to be given as an anti-tumor drug, is that TRAIL has a short half-life in serum and it has poor biodistribution (it doesn’t readily cross the blood-brain barrier). So TIC10 induces TRAIL and because TIC10 can cross the blood-brain barrier, it appears to be more efficacious than trying to administer TRAIL directly. Since TRAIL is part of the immune system, boosting it with TIC10 is thought to be less toxic than traditional chemotherapy. It remains to be seen what side effects there are from TIC10 itself.

What is FOXO and what does it have to do with this story? The TRAIL gene is transcriptionally regulated by Foxo3a. The FOXO3, also called, Forkhead box 03, is characterized by a distinct fork head DNA-binding domain and is likely a trigger for apoptosis.

Before you get too excited, the paper notes that the TIC10 group only had a 6% increase in survival compared to a more traditional anti-vascular drug, in a mouse model.

News blurb from Nature.com

Small-molecule drug drives cancer cells to suicide

http://goo.gl/rcQW8

Full article in Science Translational Medicine behind paywall.

http://goo.gl/heE1Y

Fox image from Dan Dinu: http://goo.gl/adqSb

#ScienceEveryday  when it isn’t #ScienceSunday  

Made for Each Other

Made for Each Other

NY Times review by Walter Vatter, http://goo.gl/MDw41, of 

What’s a Dog For?: The Surprising History, Science, Philosophy, and Politics of Man’s Best Friend by John Homans

(Amazon link: http://goo.gl/cOl94)

I haven’t read the book but I’m curious about the science claims. For example, that dogs understand gestures better than non-human primates.

#FidoFriday currated by mel peifer , Lisa Lisa, Suhaib Ayaz , and Wes Lum 

#ScienceEveryday