What’s in the fold?

What’s in the fold?

Congratulations! You’re a TIM (triose phosphate isomerase) barrel.

You have multiple talents and can fit in with lots of different social groups. On the surface, you might seem indistinguishable from other TIM barrels, but, in fact, you are totally unique in your subtle way.

We know how fickle some proteins can be, so we developed the all-in-one Amicon® Pro system for protein purification and antibody labeling.

Mentioning Amicon gives me flashback nightmares of grad school, filtering human red blood cell lysate (broken cells) so that I could harvest hemoglobin.

I had to search Protein Database (PDB) to see if I can display a TIM barrel on the 3D wall at work.

You can use the Jmol viewer to explore TIM.

http://www.rcsb.org/pdb/explore/jmol.do?structureId=8TIM&bionumber=1

On the right hand side, where it says Style, you can change between the different types (models) of depicting a structure: ball & stick, cartoon, space-filling, etc. Unfortunately I don’t have time for a lengthy post to explain the different models or to write more about TIM.

On the last question, in case you don’t know who Maud Menton is, she’s the Menton in the Michaelis-Menton equation. She’s also an alum of the University of Chicago.

https://en.wikipedia.org/wiki/Maud_Menten

h/t Rajini Rao 

http://www.the-scientist.com/?articles.view/articleNo/43963/title/LabQuiz–What-s-your-protein-fold-personality-/